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- Tel: 858.663.9055
- Email: info@nsjbio.com
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CD162 glycoprotein functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response.
Optimal dilution of the PSGL-1 antibody should be determined by the researcher.
Recombinant full-length human protein was used as the immunogen for the PSGL-1 antibody.
Aliquot the PSGL-1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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